AbstractLicorice root is an extremely versatile herb used both in traditional and modern medicinal applications. It is a member of the Leguminosae/Fabaceae family with two common varieties viz. Chinese licorice (Glycyrrhiza glabra) and American licorice (Glycyrrhiza uralensis), with the former being the most predominantly available. The dried roots of licorice contain many triterpenoids and hundreds of flavonoids working synergistically to support the medicinal qualities of this herb. Medicinal applications include use as an anti-inflammatory, anti-bacterial, anti-fungal, anti-diabetic, antiviral, anti-ulcer, antitussive, anti-oxidant, skin whitening, anti-diuretic agent. This article is a review of various available literature regarding traditional and modern applications of Glycyrrhiza spp.