Plasmid
Plastid
Pyrenoid
Prionoid
Nif Operon
N-linked Glycosylation
https://en.m.wikipedia.org/wiki/Pyrenoid
https://en.m.wikipedia.org/wiki/Nif_regulon
https://en.m.wikipedia.org/wiki/Nif_gene
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PYCO1
Rubisco Linker Protein
A linker protein from a red-type pyrenoid phase separates with Rubisco via oligomerizing sticker motifs
https://www.pnas.org/doi/10.1073/pnas.2304833120
Diatoms dominate marine photosynthesis, but the interactions underlying their pyrenoids are unknown.
PYCO1 is a tandem repeat protein containing prion-like domains that localizes to the pyrenoid.
Get closer and make hotspots: liquid–liquid phase separation in plants
https://www.embopress.org/doi/full/10.15252/embr.202051656
PrD
Prion‐like domain
Analysis on the complete genome sequences of multiple species, including unicellular green algae, mosses, lycophytes, liverworts, and angiosperms, has shown that PrD‐containing proteins.
A computational approach identified 474 genes encoding PrD‐containing proteins in the Arabidopsis thaliana genome.
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Lysine Pathway
Acetylation
Glutamate
Aspartate
Aminoadipate
Diaminopimelate
Chitin
Prion
Penicillin
Quantifying the Role of Lysine in Prion Replication by Nano-LC Mass Spectrometry and Bioassay
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7542330/
The introduction or deletion of lysines has been shown to significantly affect prion replication in animals.
The fungal α-aminoadipate pathway for lysine biosynthesis requires two enzymes of the aconitase family for the isomerization of homocitrate to homoisocitrate
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556520/
Crystal structures of aconitase X enzymes from bacteria and archaea provide insights into the molecular evolution of the aconitase superfamily
https://www.nature.com/articles/s42003-021-02147-5
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The suppression of prion propagation using poly-L-lysine by targeting plasminogen that stimulates prion protein conversion
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042512/
Poly-l-lysine (PLL), a homopolymer of amino acid l-lysine (LL), has been frequently used for drug delivery. Here, we report that PLL is an effective agent to inhibit propagation of prions that cause fatal and incurable neurologic disorders in humans and animals, termed prion diseases.
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Lysine
Biosynthesis
Diaminopimelate:
DAP Pathway
Aminoadipate:
AAA Pathway
Two pathways have been identified in nature for the synthesis of lysine. The diaminopimelate (DAP) pathway belongs to the aspartate derived biosynthetic family, which is also involved in the synthesis of threonine, methionine and isoleucine.
The α-aminoadipate (AAA) pathway is part of the glutamate.
Aminoadipate appears during biosynthesis of lysine in several yeast species, fungi, and certain protists.
Aminoadipate Pathway is unique to several species of yeast, higher fungi, containing chitin in their cell walls, and the euglenids.
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Vinegar Honey Salt:
Sugar-Acid
Osmolyte
Oxymel
Glycine
Lipotropic
Apple Cider Vinegar
Raw Honey
Sea Salt
Sodium
Potassium
Magnesium
Calcium
Chloride
add water & simmer down to cause a covenant bond, stabilize Ph
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5-Membered
Heterocyclic Compound
Furan (Vitamin C)
Thiazol (Vitamin B1)
The Role of Five-Membered Heterocycles in the Molecular Structure of Antibacterial Drugs Used in Therapy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675556/
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NAC
Acetyl Cysteine
Acetyl Furan
Acetylfuran
Cefuroxime
https://en.m.wikipedia.org/wiki/2-Acetylfuran
https://en.m.wikipedia.org/wiki/Cefuroxime
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Pentose Phosphate Pathway
Heterocyclic Cycle
Enzyme Activator
Mitochondria Metabolism
Transketolase Oocyte
The return of metabolism: biochemistry and physiology of the pentose phosphate pathway
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470864/
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Chloroplast DNA
https://en.m.wikipedia.org/wiki/Chloroplast_DNA
List of Sequenced Plastomes
https://en.m.wikipedia.org/wiki/List_of_sequenced_plastomes
Genome Skimming
https://en.m.wikipedia.org/wiki/Genome_skimming
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Methyl Doner
Osmolyte
Glucagon
Insulin
CHARM
Coupled Histone Autoinhibition Release Methyltransferase
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One-Carbon Metabolism
Amino Acid Synthesis
Sugar Acid (Carbon)
Amino Acid (Nitrogen)
- Sulfur Toxicity
Hyperhomocysteinemia
Cysteine - Phosphorus Toxicity
Choline
Trimethylaminuria - Nitrogen Toxicity
[Sulfur Toxicity]
Hyperhomocysteinemia
Methyl-Hydrogen-Folate
MTHFR
Methionine
Homocysteine
Cysteine
Choline
Betaine
Methylamine
Trimethylamine
Trimethylaminuria
[Nitrogen Toxicity]
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Cholinesterase
Phospholipase
Phosphodiesterase
Phosphodiester Bond
Phosphodiesterase Inhibitor
Acetylcholinesterase Inhibitor
[Prion]
Glycosylphosphatidylinositol
Glycosyl Phosphatidyl Inositol
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Phosphorylation
Acetylation Methylation
N-Linked
O-Linked
Glycosylation
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Cholinesterase
Among the most common acetylcholinesterase inhibitors are phosphorus-based compounds, which are designed to bind to the active site of the enzyme.
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5-MTHF
Methylfolate
Levomefolic Acid
TMG
Betaine
Trimethylglycerine
The Metabolic Burden of Methyl Donor Deficiency with Focus on the Betaine Homocysteine Methyltransferase Pathway
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798916/
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Insulin Resistance
Amyloid Plaque
Link between Diabetes and Alzheimer’s Disease Due to the Shared Amyloid Aggregation and Deposition Involving Both Neurodegenerative Changes and Neurovascular Damages
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357086/
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Cholinergic
Parasympathomimetic
https://en.m.wikipedia.org/wiki/Cholinergic
https://en.m.wikipedia.org/wiki/Parasympathomimetic_drug
A synapse is cholinergic if it uses acetylcholine as its neurotransmitter. A molecule must possess a nitrogen atom
(nAChRs)
Nicotinic Acetylcholine Receptor
(cGMP)
Phosphodiesterase
Choline
ATP-Sensitive
Potassium Channels
nAChRs
NO / cGMP / K+
Potassium (K) role in Carbon (C) and Nitrogen (N) balance
Choline inhibits PGE2-induced mechanical hyperalgesia by activating the α7nAChRs and NO/cGMP/K+ ATP-sensitive potassium channels
Choline attenuates inflammatory hyperalgesia activating nitric oxide/cGMP/ATP-sensitive potassium channels pathway
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054728/
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Choline
Quinoline
Glycine
Glucagon
Fenbendazole
Benzimidazole
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Heparan Sulfate
Heparan Sulfate has been found in all extracellular amyloid deposits investigated, regardless of the nature of the amyloid protein.
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Glycan
Glycosylation
Galactose Metabolism
Sugar Code
Brain Sugar
Leloir Pathway
Anabolism
Catabolism
Endergonic Reaction
Condensation Reaction
Acetylation of Sugar
Hydrolysis of Galactoside
Glycoside Hydrolase
Metabolic Myopathy
Glycine
Oxime
Acetic Acid
Glycine
Glycan
Lectin
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Emerging therapeutic potential of glycine in cardiometabolic diseases: dual benefits in lipid and glucose metabolism
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198663/
Carbohydrates:
Reactions of Sugars: Glycosylation and Protection
https://www.masterorganicchemistry.com/2018/04/24/reactions-of-sugars-glycosylation-and-protection/
Galactose in human metabolism, glycosylation and congenital metabolic diseases: Time for a closer look
https://www.sciencedirect.com/science/article/pii/S0304416521000568
Phenolic Compounds in Honey and Their Associated Health Benefits
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225430/
Fruits Vinegar: Quality Characteristics, Phytochemistry, and Functionality
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746612/
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found some kind of enzyme disfunction in digestion of Lactose Galactose Galactosemia with Diabetes.
trying to convert vinegar & honey into a kind of Glycine Galactose with the Acetyl Enzymes Activators, to help break up Insulin Resistant Plaque & feed mitochondria to induce rapid healing.
symbiont Malaria (Plastid) hidden as a Gene called (YKL40).
Chitinase-Like Protein "Genes" found in White Fly, as Endosymbionts.
Chitosan is produced commercially by deacetylation of chitin, which is the structural element in the exoskeleton of crustaceans, such as crabs and shrimp and cell walls of fungi.
Acetylation is an organic esterification reaction with acetic acid. It introduces an acetyl group into a chemical compound. Such compounds are termed acetate esters or simply acetates.
Chitosan is made by treating the Chitin crustaceans shells with an alkaline substance, such as Sodium or Potassium hydroxide.
Chitin can also be enzymatically Deacetylated to Chitosan.
my suspension is all the different Allergy pathways have to do with Sugar one-carbon metabolism, making Insulin-Amyloid Plaque, and why diabetes is related to Prion.
the sugar to protein transition, something is converting Phosphorus into plaque.
"Sugar Code" hack, Glycine/Glycan into Osmolyte using vinegar, honey & minerals, may tackle all of the above problems.
Chitin & Prion connection, how flea medicine works on dogs, makes Chitin soft, baby fleas never get a hard shell, the basic ingredients are the same as my recipe.
the other ingredient is antiparasitic via microtubule binding using sugar.
Milbemycin Oxime Lufenuron is the general idea, replacing Fluoride with charged ions.
the Thiamine binds to Prion idea is the same as the new idea, in a round about way, its connected information.
Thiamine is also an insecticide (Chitin), but not powerful enough.
Thiamine is also required for Carbohydrate metabolism.
ultimately Thiamine is not the answer, but a clue.
Milbemycin
Oxime
Lufenuron
it both softens the Chitin & kills parasites, kind of like Fenbendazole binds microtubules
honey vinegar & minerals heated down into an oil.
Carboxylic
Dicarboxylic
Tricarboxylic
Aminocarboxylic
it seems likely that rhe Honey, Vinegar & Minerals needs to be heated up for a better Functional Amino bond.
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Duarte Galactosemia
Lactose (Milk)
Gluten (Wheat)
Diabetes (Insulin)
Prion (Amyloid)
Amylose
Amyloid
Amylase
Glycoside Hydrolases
Amylase
Protein Peptide
Amylose
Carbohydrate
Prion
Amyloid
Chitin
Zymogen
Chitin
Collagen
(CLPs)
Chitinase-Like Proteins
(CHID1)
Chitinase Domain-Containing Protein 1
(CHI3L1)
Chitinase-3-Like Protein 1
(YKL)
N-Terminal Amino Acids
Tyr, Lys, and Leu
(HC-gp39)
Cartilage Glycoprotein-39
An Overview of the Protective Effects of Chitosan and Acetylated Chitosan Oligosaccharides against Neuronal Disorders
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408235/
Roles of chitinase 3-like 1 in the development of cancer, neurodegenerative diseases, and inflammatory diseases
https://www.sciencedirect.com/science/article/abs/pii/S0163725819301378
CHI3L1 YKL-40
RNA expression pattern
Top expressed in:
Pericardium
Globus Pallidus
Bone Marrow
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Chitin Synthase
Benzoylurea
N-Benzoyl-N'-Phenylurea
Milbemycin
Oxime
Lufenuron
Amyloid-Chitin Hybrid
Nanochitin Hydrogel
Chitin Solvents
Solubility of Chitin: Solvents, Solution Behaviors and Their Related Mechanisms
https://www.intechopen.com/chapters/57402
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Glycan
Polyporaceae
Polysaccharide
Turkey Tail Mushroom
Coriolus Versicolor
PSP
Polysaccharide Peptide
PSK
polysaccharide Krestin
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Mycoplasma fermentans
Binds to and Invades HeLa Cells: Involvement of Plasminogen and Urokinase
HeLa cells have 76 to 80 chromosomes, whereas normal human cells have 46.
Formerly designated Mycoplasma-like organisms are most likely Wolbachia that have evolved by becoming essential mutualistic symbionts in their respective natural hosts.
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Immortalised Cell Line
Diabetes Type 3
the reason Gulf War Syndrome & Long COVID had HIV Biomarkers, causing Diabetes Type 3, specifically plaque in the brain & cancers.
https://en.m.wikipedia.org/wiki/Immortalised_cell_line
https://en.m.wikipedia.org/wiki/Type_3_diabetes
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Raccoon Juice
HVM
Honey Vinegar Minerals
SAM
Sugar Acid Minerals
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Magnesium Dependent Osmotic, Enzymatic Activation & Methylation Transition of Hydrogen, Carbon, Nitrogen & Sulfur for Mitochondrial Metabolism ATP.
Glycine
Thiazole
Cysteine
Choline
Magnesium
Glynac
Thiamine
Fenbendazole
NAC
MSM
TMG
ACH
IHN
Acetylcysteine
Methylsulfonylmethane
Trimethylglycine
Acetylcholine
Inositol Nicotinate
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Melatonin
Methoxy
Indole
Indol
Ethyl
Melatonin is a member of the class acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a methoxy-indol-ethyl group. It is a hormone secreted by the pineal gland in humans.
Acetamide is a member of the class of acetamides that results from the formal condensation of acetic acid with ammonia.
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Glycine
Cysteine
N-Acetylcysteine NAC
GlyNAC
NAC-ET (Ethyl Ester)
GlyNAC-ET
NAC N-Acetyl-Cysteine Ethyl Ester Glycine
N-Acetylglucosamine
(GlcNAc)
https://en.m.wikipedia.org/wiki/N-Acetylglucosamine
Melatonin
vs
Serotonin
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Cationic Arginine
Gate-Keeper
L-Arginine
L-Citrulline
Neuroprotective Cationic Arginine-Rich Peptides (CARPs)
Cationic Arginine-Rich Peptides (CARPs): A Novel Class of Neuroprotective Agents With a Multimodal Mechanism of Action
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Lipofuscin
Lysosome
Chitin
Lipofuscin appears to be the product of the oxidation of unsaturated fatty acids and may be symptomatic of membrane damage, or damage to mitochondria and lysosomes.
Lipofuscin quantification is used for age determination in various crustaceans such as lobsters and spiny lobsters.
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Mycoplasma fermentans infection induces human necrotic neuronal cell death via IFITM3-mediated amyloid-β (1–42) deposition